PBMCs from SzS patients exhibit the significantly decreased ability to produce IL-12 p70, whereas production of IL-12 p40 is not significantly impaired.

(A) PBMCs from healthy donors, mycosis fungoides patients, and SzS patients with different levels of tumor burden were stimulated with SAC for 48 hours. Cytokines were measured in cell-free supernatants by radioimmunoassay. Data represent means (±SD) of tested patients. *P < .001 compared with healthy donors. (B) Blood from healthy donors and from patients with low and high tumor burden was stimulated with SAC for 5.5 hours and then stained, and lineage-negative cells were analyzed for coexpression of HLA-DR/CD11c and IL-12 p40/p70 or CD14 and IL-12 p40/p70. Right upper quadrant numbers represent the percentages of double-positive cells.