Effect of depletion of Ly49G2⁺ or Ly49C/I⁺ NK subsets in H2^bxd F₁mice on the engraftment of H2^d allografts.

Mice were given various mAb treatments or NRS 2 days before irradiation. Irradiated mice (4 mice/group) received either 0.5 × 10⁶ (A) or 4 × 10⁶ (B) parental strain C.B-17 SCID (H2^d) BMCs or 4 × 10⁶BALB/c (H2^d) BMCs (C). On the eighth day a soft agar colony assay was done to assess hematopoietic progenitor content in the spleens (mean ± SD). *Values significantly (P < .001) greater than mice receiving NRS in experiment A; **values significantly (P < .0002) greater than mice receiving NRS in experiment A; ***values significantly (P < .0001) lower than mice receiving NK1.1 in experiment B; ****values significantly (P < .02) lower than mice receiving NRS in experiment C.