Selectin deficiency protects mice from microvascular arrest induced by TNF-α and RB6-8C5.

(A-C) TNF-α/RB6-8C5–induced blood flow changes in P-selectin–deficient (A), E-selectin–deficient (B), and E-selectin/P-selectin double-deficient (C) mice. (D-F) TNF-α/RB6-8C5–induced changes in bone marrow transplantation experiments; wild-type mice given transplants of P-selectin–deficient bone marrow (D), P-selectin–deficient mice given transplants of wild-type bone marrow (E), wild-type mice given transplants of wild-type bone marrow (F). Data are shown as means ± SEMs of 1 to 3 vessels from 4 to 6 mice per group.