Fig. 3.
Fig. 3. PML-RAR induces an APL-like phenotype, and RA leads to terminal differentiation. / Histologic analysis of the bone marrow from an untreated control mouse (A, original magnification × 400), a leukemic mouse reconstituted with PML-RAR expressing cells (B, original magnification × 600, inset × 1000), and a leukemic mouse after 7 days of RA treatment (D, original magnification × 600, inset × 1000). May-Grünwald-Giemsa staining of peripheral blood smears from a PML-RAR mouse at the leukemic stage (C, original magnification × 400), and after 5 days of RA treatment (E); in the insets, a larger magnification of the same figures (original magnification × 1000). (F) Sudan black staining of APL blasts from a PML-RAR leukemic mouse (original magnification × 1000).

PML-RAR induces an APL-like phenotype, and RA leads to terminal differentiation.

Histologic analysis of the bone marrow from an untreated control mouse (A, original magnification × 400), a leukemic mouse reconstituted with PML-RAR expressing cells (B, original magnification × 600, inset × 1000), and a leukemic mouse after 7 days of RA treatment (D, original magnification × 600, inset × 1000). May-Grünwald-Giemsa staining of peripheral blood smears from a PML-RAR mouse at the leukemic stage (C, original magnification × 400), and after 5 days of RA treatment (E); in the insets, a larger magnification of the same figures (original magnification × 1000). (F) Sudan black staining of APL blasts from a PML-RAR leukemic mouse (original magnification × 1000).

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