Fig. 4.
Inhibition of ligand-dependent phosphorylation of wild-type FLT3 by SU5416 and SU5614.
RS 4;11 cells (FLT3 WT) were incubated in varying concentrations of inhibitor and treated with FL. FL-induced receptor autophosphorylation was abrogated by pretreatment with SU5416 or SU5614 with an IC50 of 100 nM and 10 nM, respectively. Total FLT3 protein expression was unaffected by treatment.
