Family tree.

The pedigree shows 5 generations. The patient under study, V-15, is indicated by an arrow. One documented case of WAS is the patient's maternal cousin (IV-23) who had an intron 6 splice site mutation, (IVS6 −1G>A). Two other relatives died in infancy of suspected WAS (II-1 and III-5). There are 6 known carrier females (III-4, III-7, III-8, IV-18, IV-19, and IV-22) in addition to the patient under study. The genotype is not defined for V-17. Symbols used are male (box), female (circle), deceased (slash), affected male (filled), female carrier (dotted fill), and unaffected subject (open symbol).