Pedigree of the family under investigation.

Males are shown as squares, females as circles, and deceased family members are crossed through. The proposita is indicated with an arrow, and family members who had experienced venous thrombosis are indicated with a T above and to the right of the symbol. Information regarding protein S levels is shown for all 6 family members for whom it was available, as indicated in the legend. For one individual, protein S levels were assessed on 2 separate occasions. DNA was available only from 2 family members. The presence of the Gly11Asp and Thr37Met mutations are indicated by a left-hand half-filled symbol and by a right-hand filled symbol, respectively (see legend). nt indicates family members for whom the genetic status was not tested; PS, protein S.