Fig. 7.
syk−/−neutrophils respond normally to chemokine LTB4 and C5a.
Functional responses and intracellular signaling events of wild-type and syk−/− neutrophils in response to LTB4 or C5a were studied as described in the legends to Figures 4-6. (A) Migration of neutrophils toward LTB4 (top panel) or C5a (bottom panel). (B) Ca2+ signal triggered by LTB4 (top panel) or C5a (bottom panel). (C) Phosphorylation of the ERK MAP kinase. (D) Actin polymerization. In panels B-D, 15 nM LTB4 or 30 ng/mL C5a was used.
