syk^−/−neutrophils respond normally to chemokine stimulation.

Functional responses and intracellular signaling events of wild-type and syk^−/− neutrophils in response to 100 ng/mL MIP-1α or 100 ng/mL MIP-2 were studied as described in the legends to Figures 4-6. (A) Release of the primary granule marker elastase during a 3-minute stimulation in the presence of CB. (B) Migration of neutrophils toward MIP-2. (C) Ca²⁺ signal triggered by MIP-1α (left panel) or MIP-2 (right panel). (D) Phosphorylation of ERK and p38 MAP kinase. (E) Actin polymerization triggered by the 2 chemokines.