Clone OtB7 is identical to the murine DC-SIGN homologue SIGNR1.

(A) Schematic representation of the genomic structure of clone OtB7. Exons are numbered and depicted as black bars. The genomic sequence was constructed by a combination of BLAST searches and multiple alignment analyses and is composed of overlapping sequences present in the GenBank entries (AC073804.1 and AC073706.2). (B) Clone OtB7 is homologous to both human DC-SIGN and L-SIGN as demonstrated by the amino acid sequence alignments of clone OtB7 (GenBank AF422108) with human DC-SIGN (AAK20997) and L-SIGN (AAK20998). Amino acid residues involved in direct ligand binding, as was shown for DC-SIGN,19 are denoted by filled arrowheads.