High-engraftment efficiency of CB CD34⁺ cells in NOD/SCID/γ$cnull$ mice.

The rate of human CD45⁺ cells was examined sequentially at the indicated times after transplantation of 1 × 10⁵ CB CD34⁺ cells into NOD/SCID/γ$cnull$ and NOD/Shi-scid mice (n = 8 each; total of 4 independent experiments). Percentage (A) and absolute number (B) of human CD45⁺ cells are shown. (C) Percentage human CD45⁺ cells in the BM and spleen of each mouse at approximately 4 months after transplantation. AGM indicates anti-asialo GM1 antibody. * P < .05;** P < .01.