Fig. 1.
Fig. 1. Domain organization of human FVIII. / FVIII circulates as a heterogenous mixture of heterodimers formed by variable intracellular processing of the B domain. The diagram shows the expected size fragments because of thrombin cleavage at Arg372, Arg740, and Arg1689. The asterisk denotes variable intracellular processing of the B domain.

Domain organization of human FVIII.

FVIII circulates as a heterogenous mixture of heterodimers formed by variable intracellular processing of the B domain. The diagram shows the expected size fragments because of thrombin cleavage at Arg372, Arg740, and Arg1689. The asterisk denotes variable intracellular processing of the B domain.

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