Location of the likely binding site for DDAbs 1 to 3.

(Left) Schematic representation of the GPIIb/IIIa complex (adapted from Humphries and Moulds,21 with permission). The assumption is made that the general conformation of GPIIb (integrin α_IIb) conforms to that of αv. (Right) Ribbon diagram depicting structure of the hybrid and PSI homology domains of GPIIIa (adapted from Xiong et al,13 with permission). The PSI homology domain was not resolved in crystallographic studies, and its location relative to the hybrid domain is unknown. In the figure, this domain has been positioned so as to bring the 3 residues shown to be essential for DDAb binding (Ala₅₀, Arg₆₂, Asp₆₆) close to one another.