Fig. 8.
Comparison of sensitivity of malignant B cells versus solid tumor cells to SAHA.
MM.1S (MM, ♦), WM-WSU (WM, ■), LNCaP (prostate carcinoma, ▵), DU145 (prostate carcinoma, ⋄), and MCF7 (breast carcinoma, ▪) cells were treated with SAHA for 36 hours. Cell survival was quantified with the MTT assay. We found that the MM cell line MM.1S and the WM cell line WM-WSU were very sensitive (IC50 of 0.16 and 0.14 μM, respectively) to SAHA. For comparison, the IC50s of LNCaP, DU145, and MCF7 lines were 12, 2.32, and 4.2 μM, respectively. A570 indicates absorbance at 570 nm.
