Fig. 6.
CD437-mediated cleavage of Bcl-XL.
WSU-CLL and ALL-REH cells were exposed to 500 nM CD437 for 0, 8, 24, or 48 hours (panel A) or 0.1, 0.25, or 0.5 μM CD437 for 48 hours (panel B) as described in the Figure 4 legend. Cells were harvested 24 hours later, and Bcl-XL cleavage was assessed by means of Western blots. Actin was used as loading control.