Effects of PPARγ modulators on CLL B cells.

Freshly isolated CLL B cells were cultured in the presence or absence of (A) 1 μM CDDO, (B) 0.5 μM CDDO-Me, or (C) 10 μM troglitazone (Trog) for 24 hours. The percentage of apoptosis was determined by double staining with annexin V–FITC and PI by means of flow cytometric analysis. Statistical significance was determined by paired t test analysis.