Profiles of immature and naive B cells in some deficient marrow specimens reveal a correlation between cycling pre-B cells and immature B cells.

Fluorescence-activated cell sorter (FACS) profiles of immature (IgM⁺CD24^hiCD38⁺IgD⁻) and naive (IgM⁺CD24^hiCD38^+/−IgD⁺) B cells from a healthy patient (A-B) are compared to a deficient one (C-D). Immature B cells were also CD10⁺ (not shown). The index of cycling pre-B cells in exceptional patient samples correlated with production of immature B cells (E), and less closely with naive B cells (F). Coefficients of determination (R²) are indicated.