Model of neutral GSL expression in human myelomonocytic differentiation.

Globo and neolacto GSLs are expressed by CFU-GMs, early myeloblasts, and monoblasts. During granulocytic maturation, globo GSL synthesis ceases, accompanied by a marked increase in total neutral GSL content. In contrast, globo and neolacto GSLs are expressed by early and late monocytes, with no apparent increase in total neutral GSL content with increasing monocytic differentiation. Adapted with permission fromBiochemistry.27 Copyright 1985, American Chemical Society.