Enhancement of RTX and mAb 1F5 C-mediated killing by mAb 3E7.

(A) Raji cells reacted with anti-CD20 mAbs RTX or 1F5 in complete medium show substantial growth after 48 hours of culture. (B-D) RTX and anti-CD20 mAb 1F5 mediate killing of Raji cells in 50% NHS, and mAb 3E7 enhances killing. Three different NHSs (O+, A+, B+) were tested in duplicate. Averages ± SD are plotted. Total live cells were determined as described in the legend to Figure 4. By 48 hours, growth is evident in the mAb 1F5–treated samples, but mAb 3E7 suppresses growth in these samples.