p57KIP2 methylation analysis in patients with ALL.

(A) p57KIP2 methylation analysis at initial presentation. Restricted band (arrow) indicates methylated allele. The number underneath each lane represents the level of methylation. (B) Analysis of p57KIP2 methylation in paired matched samples obtained at initial presentation (c) and at relapse (d). The number underneath each lane represents the level of methylation. (C) Methylation of p21CIP1 in ALL patients. (D) Methylation analysis of p14ARF in ALL patients. None of the patients analyzed had methylation of p21CIP1 or p14ARF. (Con = control cell lines).