Increased U46619-induced platelet aggregation and normal responses to ADP and thrombin with transgenic platelets.

Light transmission (%) recordings in apyrase (1 U/mL)–treated washed WT or TG mouse platelets stimulated with thromboxane A2 mimetic U46619 (1.5-1.75-2 μM) (A) or HPLC-purified ADP (5-20 μM) and thrombin (0.2 U/mL) (B). Data are representative of at least 3 independent experiments performed in duplicate on platelets from WT and TG mice.