Fig. 9.
Fig. 9. Priming of BM MN Sca-1+ cells with C3a before transplantation accelerates hematopoietic recovery and bone marrow engraftment. / (A) Leukocyte and (B) platelet recovery in the peripheral blood of lethally irradiated (900 cGy) mice that received transplants of 2 × 105 Sca-1+ cells (n = 10 mice/group). Triangles indicate mice that received transplants of untreated Sca-1+ cells; squares, mice that received transplants of Sca-1+ (1 μg/mL, 30 minutes) prestimulated with desArg-C3a (1 μg/mL, 30 minutes); diamonds, mice that received transplants of Sca-1+ cells prestimulated with C3a (1 μg/mL, 30 minutes). *P < .00001; **P < .01.

Priming of BM MN Sca-1+ cells with C3a before transplantation accelerates hematopoietic recovery and bone marrow engraftment.

(A) Leukocyte and (B) platelet recovery in the peripheral blood of lethally irradiated (900 cGy) mice that received transplants of 2 × 105 Sca-1+ cells (n = 10 mice/group). Triangles indicate mice that received transplants of untreated Sca-1+ cells; squares, mice that received transplants of Sca-1+ (1 μg/mL, 30 minutes) prestimulated with desArg-C3a (1 μg/mL, 30 minutes); diamonds, mice that received transplants of Sca-1+ cells prestimulated with C3a (1 μg/mL, 30 minutes). *P < .00001; **P < .01.

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