Evaluation of blood tests after neonatal transduction of hemophilia B dogs.

Newborn hemophilia B dogs were injected intravenously with 0.8 to 1.3 × 1010 TU/kg hAAT-cFIX–WPRE at 2 days after birth as detailed in “Materials and methods.” Blood tests were evaluated at the indicated times after the first dose of RV. For all panels, the range of normal values for that test for adult dogs is indicated by the shaded region. (A) Platelets. (B) White blood cell (WBC) count. (C) Hematocrit. (D) Creatine phosphokinase (CPK). (E) Alkaline phosphatase (Alk Phos). (F) γ-glutamyl peptidase (γGT). (G) Blood urea nitrogen (BUN). (H) Creatinine.