Fig. 2.
Fig. 2. MLL-FKHRL1–immortalized cells induce acute leukemias with latencies similar to MLL-AFX. / (A) Survival curves are shown for cohorts (n = 10) of sublethally irradiated C57BL/6 mice that were injected with MLL-FKHRL1–, MLL-AFX–, or MLL-AF10–immortalized cells or saline injected (control) mice. Differences in survival were statistically significant for MLL-FKHRL1 compared to control (P < .018) and MLL-AF10 (P < .008) cohorts but not for MLL-AFX cohort (P < .299). (B) Representative histology is shown for control and MLL-FKHRL1 mice. Leukemic blasts are present in the peripheral blood and infiltrate the portal veins of liver of moribund MLL-FKHRL1 mice (original magnification, × 400). Blood smears were stained with May-Grünwald-Giemsa; paraffin sections were stained with hematoxylin and eosin (original magnification, × 200).

MLL-FKHRL1–immortalized cells induce acute leukemias with latencies similar to MLL-AFX.

(A) Survival curves are shown for cohorts (n = 10) of sublethally irradiated C57BL/6 mice that were injected with MLL-FKHRL1–, MLL-AFX–, or MLL-AF10–immortalized cells or saline injected (control) mice. Differences in survival were statistically significant for MLL-FKHRL1 compared to control (P < .018) and MLL-AF10 (P < .008) cohorts but not for MLL-AFX cohort (P < .299). (B) Representative histology is shown for control and MLL-FKHRL1 mice. Leukemic blasts are present in the peripheral blood and infiltrate the portal veins of liver of moribund MLL-FKHRL1 mice (original magnification, × 400). Blood smears were stained with May-Grünwald-Giemsa; paraffin sections were stained with hematoxylin and eosin (original magnification, × 200).

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