Relationship of CA 13 or hypodiploidy at relapse and short subsequent survival.

Cytogenetic abnormalities involving chromosome 13 (CA 13) or hypodiploidy at relapse imparts short subsequent survival. Left panel: Kaplan-Meier plots of overall survival dated from the onset of relapse on Total Therapy I. The majority of patients without cytogenetic abnormalities (no CA) had a significantly longer survival than those with other CAs and especially those with hypodiploidy or CA 13. Right panel: additional consideration of pretherapy cytogenetic abnormalities separates, among those without CA at relapse, those with no CAs, also at diagnosis, as having the best survival whereas those without CAs at relapse but CAs at diagnosis had intermediate outcome.