Fig. 7.
Fig. 7. Cell cycle– and chromosome-related genes in FISH 13/CA subgroups. / Cell cycle– and chromosome-related genes distinguish FISH 13/CA subgroups. The “shrunken centroids” method20 was applied to reveal significant differences across 4 MM subgroups on the basis of 30 genes having at least one nonzero difference (17 related to cell cycle/DNA metabolism, 3 genes of unknown function, and 10 mapping to chromosome 13). The genes with nonzero components in each class are mutually exclusive. The length of horizontal bars for a given gene represents the difference between the overall centroid (vertical axes) and each of the 4 subgroup centroids. Bars to the left indicate lower expression in subgroups relative to the overall centroid; bars to the right indicate higher expression in subgroups relative to the overall centroid. The gene order, from top to bottom, is based on the greatest difference (with the bar longest at top) between the overall centroid and any 1 of the 4 group centroids. Kruskal-Wallis test Pvalues for difference between each group centroid and the overall centroid for all comparisons are indicated. Background colors distinguish different gene groups: pink, chromosome 13 genes; yellow, cell cycle genes; green, DNA metabolism genes; cyan, genes with unknown function. Note: FISH 13/no CA (45 patients) is characterized by uniformly left-sided bars (underexpression of both cell cycle/DNA metabolism– and chromosome 13–related genes). No FISH 13/CA (30 patients) show mainly right-sided bars, indicative of expression of both cell cycle/DNA metabolism– and chromosome 13–related genes. No FISH 13/no CA (37 patients) is characterized by overexpression of chromosome 13 genes (right-sided bars) and underexpression of all 17 cell cycle/DNA metabolism–related and 3 unknown function genes (left-sided bars). FISH/CA (34 patients) shows the mirror image of no FISH/no CA in that all cell cycle/DNA metabolism genes are hyperactivated (more so than in the no FISH 13/CA group) and chromosome 13 genes are inactivated (more so than in the FISH 13/no CA group).

Cell cycle– and chromosome-related genes in FISH 13/CA subgroups.

Cell cycle– and chromosome-related genes distinguish FISH 13/CA subgroups. The “shrunken centroids” method20 was applied to reveal significant differences across 4 MM subgroups on the basis of 30 genes having at least one nonzero difference (17 related to cell cycle/DNA metabolism, 3 genes of unknown function, and 10 mapping to chromosome 13). The genes with nonzero components in each class are mutually exclusive. The length of horizontal bars for a given gene represents the difference between the overall centroid (vertical axes) and each of the 4 subgroup centroids. Bars to the left indicate lower expression in subgroups relative to the overall centroid; bars to the right indicate higher expression in subgroups relative to the overall centroid. The gene order, from top to bottom, is based on the greatest difference (with the bar longest at top) between the overall centroid and any 1 of the 4 group centroids. Kruskal-Wallis test Pvalues for difference between each group centroid and the overall centroid for all comparisons are indicated. Background colors distinguish different gene groups: pink, chromosome 13 genes; yellow, cell cycle genes; green, DNA metabolism genes; cyan, genes with unknown function. Note: FISH 13/no CA (45 patients) is characterized by uniformly left-sided bars (underexpression of both cell cycle/DNA metabolism– and chromosome 13–related genes). No FISH 13/CA (30 patients) show mainly right-sided bars, indicative of expression of both cell cycle/DNA metabolism– and chromosome 13–related genes. No FISH 13/no CA (37 patients) is characterized by overexpression of chromosome 13 genes (right-sided bars) and underexpression of all 17 cell cycle/DNA metabolism–related and 3 unknown function genes (left-sided bars). FISH/CA (34 patients) shows the mirror image of no FISH/no CA in that all cell cycle/DNA metabolism genes are hyperactivated (more so than in the no FISH 13/CA group) and chromosome 13 genes are inactivated (more so than in the FISH 13/no CA group).

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