Time courses of NPP induction and Hb consumption by P falciparum parasites during their 48-hour asexual reproduction cycle in human red cell hosts as encoded in the homeostatic model of IRBCs.

The curves follow the equation given in the figure. They represent the patterns observed by Staines et al15 for Y = NPP_K and by Krugliak et al2 for Y = Hb (or H), and are shown in the figure normalized to maximal values of 1. The default parameter values used in the model and in the simulations of Figures 2 and 5 (unless specified otherwise) were for Y = NPP_K, NPP_K-max = 1.1 h⁻¹,t_1/2 = 27 hours ands = 3, and for Y = H, H_max = 70%,t_1/2 = 32 hours and s = 3. These values compare with those measured as follows: for NPP_K,t_1/2 = approximately 27 hours, and NPP_K-max = approximately 1 h⁻¹ (Staines et al15; estimated from their Figures 2 and 7); for H,t_1/2 = approximately 32 hours, and H_max = 65% (Krugliak et al2; estimated by combining data from their Figures 2, 3, and 4).