Liposomal clodronate effectiveness and dosage.

Liposomal clodronate is effective over a wide dose range. Mice were injected with the indicated doses of clodronate or PBS liposomes. At 36 hours later, they were injected with CFSE-labeled, antibody-opsonized RBCs (5 × 10⁸). Control mice received an identical number of nonopsonized RBCs. Persistence of circulating, labeled RBCs was assessed by tail bleed 4 hours later. Data are expressed as percentages of circulating RBCs that were CFSE⁺ (± standard errors). Data presented are from 1 experiment representative of 3.