Plasma FVIII and VWF levels in MX1cre⁺LRP^flox/flox and control LRP^flox/flox mice.

MX1cre⁺LRP^flox/flox mice () (n = 29) and control LRP^flox/flox mice (○) (n = 18) were injected 3 times intraperitoneally with 250 μg pI:pC at 2-day intervals. At 10 days after the final pI:pC injection, blood was drawn and plasma was analyzed for FVIII and VWF, as described in “Materials and methods.” (C) Replotting of individual FVIII levels (A) against the corresponding VWF levels (B).