Chimeras that have been cured of metastatic breast cancer exhibit CTL activity against tumor cells but tolerance of normal host antigens.

Splenocytes from representative cured animals (●, ○), from unprimed BALB/c mice (▾), or from B10.D2 mice primed previously with BALB/c cells (▴) were cultured for 5 days with irradiated 4T1 cells or BALB/c splenocytes and then tested for killing of 4T1 (A) or BALB/c (B) targets in a 4-hour chromium release assay.