Fig. 2.
Visualization of leukemic bone marrow infiltration by BLI.
(A) Leukemic infiltration of the BM of sublethally irradiated BALB/c mice as revealed by whole body BLI one week after intravenous injection of 2 × 104 A20-luc/yfp cells into sublethally irradiated BALB/c mice (4 Gy). The scale to the left of the images describes the color map for the photon count. (B) Tumor expansion as quantified by measuring the photon counts of individual animals (n = 4) emitted at the time points indicated. (C) FACS analysis of BM cells from the femur 21 days after tumor inoculation revealed that 61% of the BM cells were CD19+, YFP+ tumor cells.
