Tumor regression in response to chemotherapy and irradiation therapy.

BALB/c mice were engrafted with 2 × 10³BCL₁-gfp/luc lymphoma cells, and tumor growth was quantified by BLI 14 days after tumor inoculation. Groups of animals received either (A) no further treatment (n = 3), (B) 2 × 40 mg/kg cyclophosphamide intraperitoneally within 24 hours (n = 5), or (C) total body irradiation with 8 Gy followed 24 hours later by a syngeneic bone marrow transplantation (n = 4). Tumor growth, regression, and relapse were determined by BLI 2 days and 4 days after treatment and in weekly intervals thereafter.