Germ-line donors used by the AL light chain variable gene families.

(A) Germ-line gene donors for the Vκ gene families. The Vκ category was represented by 4 Vκ families—Vκ I, Vκ II, Vκ III, and Vκ IV. The Vκ I family was the most widely used and represented by several germ-line genes, with O18/O8and O12/O2 being the most common. Only a single Vκ II patient was present of the 26 patients. A single donor B3represented the Vκ IV gene family. Each germ-line gene is represented as percent of patients using the specific gene within a given Vκ family. (B) The germ-line donors used by λ AL patients are shown. The Vλ I family was represented by germ-line genes1b, 1c, and 1e, whereas the Vλ II family primarily used 2a2, 2b2, and2c. Vλ III and Vλ VI were each represented as a single dominant germ-line donor, 3r and 6a, respectively. The Vλ II group was used most frequently in the λ category. Each germ-line gene is represented as percent of patients using the specific gene within a given Vλ family.