Kaplan-Meier survival curves for the AL subset.

Panel A shows a comparison of the overall survival between the κ (thick line) and λ (thin line) groups within the selected subset. Panel B shows survival based on Vκ gene use (Vκ I [solid line] and Vκ IV [dashed line] gene families). The single Vκ II patient has not been represented, and because of the small numbers of patients in the subgroups, survival for individual germ-line genes has not been shown. The Vκ IV gene, which is associated mainly with cardiac and renal amyloidosis, showed reduced survival. Panel C shows survival analysis for the Vλ gene families. Vλ II patients present predominantly with cardiac infiltration and have reduced survival, whereas Vλ VI patients have comparatively better survival curves. The clinical categories documented are not mutually exclusive.