Peptide Ac2-26 inhibits albumin leakage in inflamed mesenteries of WT and FPR KO mice.

Mice were administered, through the jugular vein, PBS (100 μL; vehicle group) or peptide Ac2-26 (100 μg corresponding to 33 nmol) at the beginning of the reperfusion period (ie, 30 minutes after ischemia). FITC-labeled albumin was infused and allowed to circulate for 5 to 10 minutes, prior to analysis that was performed 45 minutes into the reperfusion period. As in the experiments in Figures 2 and 3, a sham group (75 minutes) was run in parallel. In addition, a sham group in which albumin leakage was determined immediately after laparoctomy (time 0) was also used. (A) Wild-type mice; (B) FPR KO mice. Data are mean ± SEM of n = 6 mice per group, with the exception of sham (time 0) where n = 3. *P < .5 versus respective vehicle-treated group.