Proliferation of TpM409 is Src kinase dependent.

(A) TpM409 cells were treated with increasing concentrations of PP2, and thymidine incorporation was measured after 3, 24, 48, and 72 hours. (B) PP2-induced growth arrest is overcome by phorbol-ester stimulation. Cells were treated with PP2 and PMA as indicated, and thymidine incorporation was quantified after 24 hours. Error bars indicate mean and standard deviation of 3 independent experiments.