Fig. 10.
Fig. 10. Apoptosis ofCD18+/+ andCD18−/− PMNs derived fromCD18+/+/CD18−/−chimeric mice. / (A) Flow cytometric analysis of DNA content measured in PI-stainedCD18+/+ andCD18−/− PMNs isolated from the circulation ofCD18+/+/CD18−/−chimeric mice and aged for 4 hours in culture without further stimulation (n = 3). Data represent apoptotic PMNs with a loss of DNA content in percent of total cell number. Data represent means ± SDs; NS indicates not significant. (B) Flow cytometric analysis of CD16 expression on the cell surface ofCD18+/+ andCD18−/− PMNs in whole blood samples obtained from the circulation ofCD18+/+/CD18−/−chimeric mice and aged for 0 and 4 hours in culture without further stimulation using the FITC-labeled anti-CD16 mAb and the PE-labeled anti-CD18 mAb. Data represent apoptotic PMNs with diminished CD16 expression in percent of total cell number. Means ± SDs are shown; NS indicates not significant.

Apoptosis ofCD18+/+ andCD18−/− PMNs derived fromCD18+/+/CD18−/−chimeric mice.

(A) Flow cytometric analysis of DNA content measured in PI-stainedCD18+/+ andCD18−/− PMNs isolated from the circulation ofCD18+/+/CD18−/−chimeric mice and aged for 4 hours in culture without further stimulation (n = 3). Data represent apoptotic PMNs with a loss of DNA content in percent of total cell number. Data represent means ± SDs; NS indicates not significant. (B) Flow cytometric analysis of CD16 expression on the cell surface ofCD18+/+ andCD18−/− PMNs in whole blood samples obtained from the circulation ofCD18+/+/CD18−/−chimeric mice and aged for 0 and 4 hours in culture without further stimulation using the FITC-labeled anti-CD16 mAb and the PE-labeled anti-CD18 mAb. Data represent apoptotic PMNs with diminished CD16 expression in percent of total cell number. Means ± SDs are shown; NS indicates not significant.

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