Fig. 4.
Fig. 4. Effect of imatinib mesylate on G-CSF–induced granulocytic differentiation of 32DBcr-Ablwt cells. / Imatinib mesylate restores G-CSF–induced granulocytic differentiation of 32DBcr-Ablwt cells. (A) 32Dcl3 cells and 2 individual clones of 32DBcr-Ablwt cells were grown in media containing G-CSF. Imatinib mesylate was added at a concentration of 1 μM as indicated. Morphological differentiation of cytospun cells was determined at days 8 and 11 by May-Gruenwald-Giemsa staining (original magnification, × 400). Cells grown in the presence of IL-3 are shown as a control. (B) Expression of Gr-1 and Mac-1 on 32Dcl3 cells and 32DBcr-Ablwt cells upon G-CSF stimulation. Addition of 1 μM imatinib mesylate to the media sufficiently restored up-regulation of both myeloid surface markers.

Effect of imatinib mesylate on G-CSF–induced granulocytic differentiation of 32DBcr-Ablwt cells.

Imatinib mesylate restores G-CSF–induced granulocytic differentiation of 32DBcr-Ablwt cells. (A) 32Dcl3 cells and 2 individual clones of 32DBcr-Ablwt cells were grown in media containing G-CSF. Imatinib mesylate was added at a concentration of 1 μM as indicated. Morphological differentiation of cytospun cells was determined at days 8 and 11 by May-Gruenwald-Giemsa staining (original magnification, × 400). Cells grown in the presence of IL-3 are shown as a control. (B) Expression of Gr-1 and Mac-1 on 32Dcl3 cells and 32DBcr-Ablwt cells upon G-CSF stimulation. Addition of 1 μM imatinib mesylate to the media sufficiently restored up-regulation of both myeloid surface markers.

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