Fig. 5.
Fig. 5. Schema of early and late immunoregulatory functions of the CD56bright NK cell subset. / Early during the innate immune response, CD56bright NK cells are costimulated with monokines (eg, IL-12 plus IL-18, IL-15, IL-1β) to produce IFN-γ. Later, CD56bright NK cells may use T cell–derived IL-2 and APC-derived IL-12 to synergistically induce IFN-γ, which may then influence the developing adaptive immune response. TCR indicates T-cell receptor.

Schema of early and late immunoregulatory functions of the CD56bright NK cell subset.

Early during the innate immune response, CD56bright NK cells are costimulated with monokines (eg, IL-12 plus IL-18, IL-15, IL-1β) to produce IFN-γ. Later, CD56bright NK cells may use T cell–derived IL-2 and APC-derived IL-12 to synergistically induce IFN-γ, which may then influence the developing adaptive immune response. TCR indicates T-cell receptor.

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