Fig. 6.
Fig. 6. Histologic evidence of BM hypoplasia and myelofibrosis. / (A) H&E staining of the BM from a mouse transplanted withFancc+/+ cells (magnification × 100). (B) H&E staining of the spleen from a mouse transplanted withFancc+/+ cells (magnification × 100). (C) H&E staining of the BM from mouse 3 (magnification × 100). (D) Magnification × 200 revealed a hypoplastic marrow. (E) H&E staining of the spleen from mouse 3 (magnification × 200). (F) Magnification ×  400 revealed abnormal splenic architecture with an increased number of immature myeloid cells. (G) H&E staining of the BM from mouse 6 (magnification × 200). (H-I) Magnification ×  400 revealed a hypercellular BM with a marked degree of myeloid hyperplasia and significant myelofibrosis. (J) Reticulin staining of the BM from mouse 6 (magnification × 400) to identify collagen deposition, which confirms myelofibrosis.

Histologic evidence of BM hypoplasia and myelofibrosis.

(A) H&E staining of the BM from a mouse transplanted withFancc+/+ cells (magnification × 100). (B) H&E staining of the spleen from a mouse transplanted withFancc+/+ cells (magnification × 100). (C) H&E staining of the BM from mouse 3 (magnification × 100). (D) Magnification × 200 revealed a hypoplastic marrow. (E) H&E staining of the spleen from mouse 3 (magnification × 200). (F) Magnification ×  400 revealed abnormal splenic architecture with an increased number of immature myeloid cells. (G) H&E staining of the BM from mouse 6 (magnification × 200). (H-I) Magnification ×  400 revealed a hypercellular BM with a marked degree of myeloid hyperplasia and significant myelofibrosis. (J) Reticulin staining of the BM from mouse 6 (magnification × 400) to identify collagen deposition, which confirms myelofibrosis.

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