Fig. 5.
Functional FVIII expression in FVIIIKO mice following transient macrophage depletion.
Mice were treated with clodronate liposomes (black lines) 1 day before the injection of Ad-AAT-cFVIII vectors at different doses: 5 × 109 (A), 108 (B), 5 × 107(C), 107 (D), and 5 × 106 IU (E). Littermates were injected with PBS-containing liposomes as controls. Littermates were injected with PBS-containing liposomes as controls (gray lines). The detection limit of the assay corresponds to 30 mU/mL and was indicated on the graph by a dotted line.
