Binding mode of the dual-specific Src/Abl kinase inhibitors PP1 and CGP76030.

Phospho-Abl and Abl immunoblots of lysates from Cos7 cells transfected with pApuro, Bcr-Ablwt, or the indicated mutants of Bcr-Abl at positions 315 and 380. Cells were either left untreated or incubated with 25 μM CGP76030 or 100 μM PP1.