IL-7 therapy increases CD4⁺ and CD8⁺ T cells in the peripheral blood.

(A) Reversible increases in CD3⁺/CD4⁺lymphocytes in peripheral blood are expressed as percent change from baseline. Each line represents individual animals treated with 50 μg/kg/d (red), 200 μg/kg/d (blue), and 500 μg/kg/d (green). Dotted lines represent untreated animals. (B) Similar changes observed in peripheral blood CD3⁺/CD8⁺lymphocytes. (C) Absolute number of CD3⁺/CD4⁺ and CD3⁺/CD8⁺lymphocytes on day 11 (1 day after stopping IL-7 therapy). Each data point represents an individual animal. (D) No change in CD4/CD8 ratio.