Fig. 3.
Fig. 3. Treatment with IL-7 induces profound peripheral T-cell cycling. / (A) Transient and marked increase in the percentage of Ki67+/CD4+ and Ki67+/CD8β T cells with IL-7 treatment. The numbers in the upper quadrant are the percentage of CD4+ and CD8β+ cells that stain with Ki67. (B) Increased BrdU uptake by CD4+ and CD8β+ T cells during 18 hour ex vivo culture initiated following in vivo exposure to IL-7. (C) Reversible decrease in p27kip1 and p16Ink4a proteins in peripheral blood mononuclear cells following IL-7 treatment. The ratio of p27kip1 and p16Ink4a to tubulin densitometry readings are shown below each lane.

Treatment with IL-7 induces profound peripheral T-cell cycling.

(A) Transient and marked increase in the percentage of Ki67+/CD4+ and Ki67+/CD8β T cells with IL-7 treatment. The numbers in the upper quadrant are the percentage of CD4+ and CD8β+ cells that stain with Ki67. (B) Increased BrdU uptake by CD4+ and CD8β+ T cells during 18 hour ex vivo culture initiated following in vivo exposure to IL-7. (C) Reversible decrease in p27kip1 and p16Ink4a proteins in peripheral blood mononuclear cells following IL-7 treatment. The ratio of p27kip1 and p16Ink4a to tubulin densitometry readings are shown below each lane.

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