Fig. 1.
Expression of the Pgp
MDR-1 gene product in K562 and K562/DOX. (A) Flow cytometric analysis of Pgp expression in K562 and K562/DOX: (1) isotypic control for K562/DOX; (2) isotypic control for K562; (3) Pgp for K562; (4) Pgp for K562/DOX. (B) Caspase-3 activity in 105 cells after 24 hours in culture without (■, control) or with (1 μM) imatinib (░). Results represent the mean ± SD of triplicate cultures. The difference between the 2 treated cultures is statistically significant (P = .004; Student t test).
