Morphologic appearance of

P falciparum in CC and AA cells. Parasite clone GB4 was cultured for 4 days in either AA or CC cells, stained with Giemsa, and observed by light microscopy (× 1000). Although healthy forms (asterisks) were noted in CC cells, typically half of all parasites appeared to be unhealthy, as indicated by fragmentation of ring forms and blurring of trophozoites and schizonts (top panels arrows). The healthy condition of parasites in AA cells is shown for comparison (bottom panels).