![Fig. 1. Fluoxetine promotes growth cessation in biopsy-like Burkitt lymphoma cells. / L3055 cells were treated for 24 hours with (A) 0.5 to 30 μM fluoxetine; (B) 0.5 to 30 μM paroxetine; and (C) 1 to 150 μM citalopram; EC50 values of DNA synthesis inhibition for each of the SSRIs are indicated. (D) 5 group I BL lines and the group III cell line “Mutu III” were treated for 24 hours with fluoxetine (20 μM, ░), paroxetine (20 μM, ■), or citalopram (100 μM, ▪), and resultant DNA synthesis expressed as percent control. (E) L3055 cells cultured for 24 hours either alone (▪), with fluoxetine (20 μM, ■), or with anti-μ chain antibody (10 μg/mL, ░), and viable population subjected to cell-cycle analysis. (F) L3055 cells pretreated for 1 hour with soluble CD40L trimer were then cultured for 24 hours before analysis of DNA synthesis (3[H]-thymidine) and cell viability (FACS); results are percent change due to presence of 20 μM fluoxetine. All data are means ± SEMs, from 8 separate experiments for panel A; 6, for panels B-D; and 3, for panels E-F.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/101/8/10.1182_blood-2002-07-2044/4/h80834123001.jpeg?Expires=1735840605&Signature=j-i0O3p1SvJ~KA4xDXw0qGSIXU37wJD~aOiViT21223kl2aatlXEyNmSldXLh5dhnDfjT-4LZ1ZC5Z4GQUbm5DULX3sN9QuXq~YYuZUl09WgYgCHQZhCWg3R8cFka2BE~-9qvzznxUCBVdc48ja0TuzTDGwD5JZ3CIaSAK-Ol7KhaeKCoNKxOaPKMMJGRqB~HlwAELJuiBH3q5WDfQ2XL0kevImxcWE3YycUlicwyNj21IM-uNGyIr41Q3Tj87X-68IBlJUu44v-lnlIgmH47vbxd8pSRHcsvf249FWwD03fxytdT92y-y0iFdMokvtAlIu4tmXatqSHR1PMP8g0XQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Fluoxetine promotes growth cessation in biopsy-like Burkitt lymphoma cells.
L3055 cells were treated for 24 hours with (A) 0.5 to 30 μM fluoxetine; (B) 0.5 to 30 μM paroxetine; and (C) 1 to 150 μM citalopram; EC50 values of DNA synthesis inhibition for each of the SSRIs are indicated. (D) 5 group I BL lines and the group III cell line “Mutu III” were treated for 24 hours with fluoxetine (20 μM, ░), paroxetine (20 μM, ■), or citalopram (100 μM, ▪), and resultant DNA synthesis expressed as percent control. (E) L3055 cells cultured for 24 hours either alone (▪), with fluoxetine (20 μM, ■), or with anti-μ chain antibody (10 μg/mL, ░), and viable population subjected to cell-cycle analysis. (F) L3055 cells pretreated for 1 hour with soluble CD40L trimer were then cultured for 24 hours before analysis of DNA synthesis (3[H]-thymidine) and cell viability (FACS); results are percent change due to presence of 20 μM fluoxetine. All data are means ± SEMs, from 8 separate experiments for panel A; 6, for panels B-D; and 3, for panels E-F.
