Biodistributions of radioactivity in blood, tumor, kidney, liver, muscle, small intestine, colon, spleen, stomach, and lung.

Ramos xenograft-bearing athymic mice were injected with directly radiolabeled BC8 antibody (A) or 1F5 antibody (B). Mice were coinjected with 1.4 nmol conventional trace-labeled ¹²⁵I-BC8 and 1.4 nmol ¹³¹I-1F5 antibodies. Groups of 5 mice were killed 24, 48, and 72 hours after injection of the radiolabeled antibodies and after the radioactivity in blood, tumor, kidney, liver, and lung was quantified by gamma counting and expressed as the percentage of the injected dose of radioactivity present per gram of tissue (% ID/g). Tumor (●), blood (○), kidney (▴), liver (*), lung (⋄).