Kaplan-Meier analysis of cumulative survival of mice bearing Ramos lymphoma xenografts treated with pretargeted radioimmunotherapy.

Groups of 10 mice bearing approximately 100 mm³ Ramos tumor xenografts were treated as described in the legend to Figure 4 and analyzed for survival as a function of time. Treatment groups included mice treated with (1) 1.4 nmol BC8-SA conjugate, followed 20 hours later by 5.8 nmol clearing agent, and 2 hours after that with 800 μCi (29.6 MBq) (A), 400 μCi (14.8 MBq) (B), or 200 μCi (7.4 MBq) (C)⁹⁰Y-DOTA-biotin or (2) 1.4 nmol 1F5-SA conjugate, followed 20 hours later by 5.8 nmol clearing agent and 2 hours after that with 800 μCi (29.6 MBq) (D), 400 μCi (14.8 MBq) (E), and 200 μCi (7.4 MBq) (F) of ⁹⁰Y-DOTA-biotin. The letters A-F in this figure correspond to treatment groups designated in panels A-F in Figure4.