Fig. 10.
Fig. 10. TH1 versus TH2 response is not increased by CD95L-DCs in IL1R−/− mice. / 3 × 105 lpr/lpr bm12 CD95L or control DCs were inoculated subcutaneously into the footpad of C57BL/6 wild-type (WT) or C57BL/6 IL-1R−/− mice. Five days later, draining LN cells were cocultured with syngeneic (C57BL/6; white bars), allogeneic (lpr/lpr bm12; black bars), or third-party (BALB/c; gray bars) spleen cells for 3 days. Supernatants were collected after 72 hours for IFN-γ and IL-5 measurement. Results are expressed as mean of IFN-γ/IL-5 production ± SEM of 6 to 8 mice for the WT group and 4 to 7 mice for the IL-1R−/− group (*P < .02). NT indicates nontreated mice.

TH1 versus TH2 response is not increased by CD95L-DCs in IL1R−/− mice.

3 × 105 lpr/lpr bm12 CD95L or control DCs were inoculated subcutaneously into the footpad of C57BL/6 wild-type (WT) or C57BL/6 IL-1R−/− mice. Five days later, draining LN cells were cocultured with syngeneic (C57BL/6; white bars), allogeneic (lpr/lpr bm12; black bars), or third-party (BALB/c; gray bars) spleen cells for 3 days. Supernatants were collected after 72 hours for IFN-γ and IL-5 measurement. Results are expressed as mean of IFN-γ/IL-5 production ± SEM of 6 to 8 mice for the WT group and 4 to 7 mice for the IL-1R−/− group (*P < .02). NT indicates nontreated mice.

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